KRAB-ZFP Repressors Enforce Quiescence of Oncogenic Human Herpesviruses
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چکیده
منابع مشابه
Oncogenic herpesviruses sending mixed signals.
Human herpesvirus infections are generally asymptomatic in immune-competent hosts; however, immune dysfunction can unveil inherent oncogenic properties associated with Epstein-Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) infection. Although these viruses were first discovered in human tumor specimens in 1964 and 1994, respectively, it was discovered later on that large proportions o...
متن کاملUtilising proteomic approaches to understand oncogenic human herpesviruses (Review).
The γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are successful pathogens, each infecting a large proportion of the human population. These viruses persist for the life of the host and may each contribute to a number of malignancies, for which there are currently no cures. Large-scale proteomic-based approaches provide an excellent means of increasing the colle...
متن کاملReviews Evolutionary aspects of oncogenic herpesviruses
Several of the ã-herpesviruses are known to have cellular transforming and oncogenic properties. The genomes of eight distinct ã-herpesviruses have been sequenced, and the resulting database of information has enabled the identification of genetic similarities and diVerences between evolutionarily closely related and distant viruses of the subfamily and between the ã-herpesviruses and other mem...
متن کاملVaccination of nonhuman primates with killed oncogenic herpesviruses.
Killed herpesvirus cancer vaccines were prepared by inactivation of oncogenic herpesviruses (Herpesvirus saimiri and Herpesvirus ateles) with heat and formaldehyde. The killed vaccines, which are not free of viral nucleic acid, were safe in 121 vaccinated monkeys of 4 different species. Some of these monkeys have now been under observation for 2 years. The vaccines induced high titers of specif...
متن کاملConcentration of oncogenic herpesviruses by methyl alcohol precipitation.
Oncogenic herpesviruses, like many other viruses, can be concentrated effectively from large volumes of culture fluids by precipitation with methanol with good recovery of infectivity.
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2018
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00298-18